Is CBD Safe?

While currently unregulated by the Food and Drug Administration ("FDA") in the US, multiple studies compiled by the National Intitutes of Health ("NIH") suggest that generally, CBD is well-tolerated in humans and pets. 


In Safety and side effects of cannabidiol, a Cannabis sativa constituent, study authors conclude:


"Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy (a medical condition characterized by a trance or seizure, loss of consciousness or body rigidity), does not affect physiological parameters (heart rate, blood pressure and body temperature), does not affect gastrointestinal transit and does not alter psychomotor or psychological functions. Also, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Conversely, some studies reported that this cannabinoid can induce some side effects, including inhibition of hepatic drug metabolism (the inability to optimally process certain medications), alterations of in vitro cell viability (cellular health), decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters. Based on recent advances in cannabinoid administration in humans, controlled CBD may be safe in humans and animals. However, further studies are needed to clarify these reported in vitro and in vivo side effects." Comments in parentheses added for clarification.   


What this means is that a review undertaken by researchers at the NIH concluded that several studies indicated CBD as non-toxic and non-interactive across physiological and psychological parameters. It also notes, however, that some studies, in contrast, note there there could be certain side effects. Clearly noting that more study is needed, the researchers suggest that CBD, however, may be safe in both humans and animals. 


Side Effects   

While some people may experience no side effects, some people may, including:

                             nausea                           dry mouth                              fatigue

                             irritability                       digestive issues                    agitation

                             reduced appetite          drowsiness                            pharmacological interactions


CBD may also interact with the blood thinner Coumadin (Warfarin), and can potentially raise levels of certain other medications in the body similarly to the grapefruit effect. The grapefruit effect is where the juice physically inhibits the production of certain metabolizing enzymes resulting in a higher than recommended dosage of the medication remaining in the body over a longer period of time. As CBD and its partner cannabinoids interact with the enzymes in the endocannabinoid system, it is possible that a similar effect could be recognized when used in conjunction with certain other medications. Should you currently be on a consistent medication schedule (especially related to cholesterol, hypertension, organ rejection, anxiety, Crohn's, irregular heartbeat, or certain antihistamines), please consult your health care provider prior to commencing any CBD, or CBD-related regimen.  


What To Do If You Experience Intolerable Side Effects




If you experience any unwanted or intolerable side effects, immediately discontinue using CBD. You may continue to feel the impact of side effects until your body fully metabolizes the CBD you have taken. Generally any impact will dissipate in about 24 hours.